Epc1 | enhancer of polycomb homolog 1

GeneMGI:1278322Synonyms: A930032N02Rik, 5730566F07Rik, +1 more

Physiological systems

19 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Growth/size/body region Hematopoietic system Skeleton Mortality/aging

13 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:7Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



decreased body weight	1 supporting dataset	Epc1^{tm1e(EUCOMM)Wtsi}	homozygote	Early adult	2.45x10^-13
abnormal bone mineralization	1 supporting dataset	Epc1^{tm1e(EUCOMM)Wtsi}	heterozygote	Early adult	2.41x10^-6
increased lactate dehydrogenase level	1 supporting dataset	Epc1^{tm1e(EUCOMM)Wtsi}	heterozygote	Early adult	7.15x10^-6
decreased leukocyte cell number	1 supporting dataset	Epc1^{tm1e(EUCOMM)Wtsi}	heterozygote	Early adult	4.37x10^-5
increased lean body mass	1 supporting dataset	Epc1^{tm1e(EUCOMM)Wtsi}	heterozygote	Early adult	6.91x10^-5
preweaning lethality, incomplete penetrance	1 supporting dataset	Epc1^{tm1e(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
increased bone mineral density	1 supporting dataset	Epc1^{tm1e(EUCOMM)Wtsi}	heterozygote	Early adult	8.47x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Epc1.

Associated images

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Histopathology

There is no histopathology data found for Epc1.

IMPC related publications

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External links

No external links available for Epc1.

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*Epc1^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Epc1^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	mouse

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