Epc2 | enhancer of polycomb homolog 2
Physiological systems
22 / 24 physiological systems tested
8 Significantly impacted by the knock-out
Homeostasis/metabolism Pigmentation Vision/eye Respiratory system Hematopoietic system Behavior/neurological Cardiovascular system Mortality/aging
14 No significant impact
2 Not tested
Data collections
Gene metrics:16Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal retina morphology | 1 supporting dataset | Epc2tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 2.77x10-5 | ||
| increased circulating alkaline phosphatase level | 1 supporting dataset | Epc2tm1a(EUCOMM)Wtsi | homozygote | Early adult | 8.85x10-6 | ||
| increased thigmotaxis | 2 supporting datasets | Epc2tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 5.82x10-5 | ||
| decreased lactate dehydrogenase level | 1 supporting dataset | Epc2tm1a(EUCOMM)Wtsi | homozygote | Early adult | 3.01x10-6 | ||
| cataract | 1 supporting dataset | Epc2tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 3.23x10-8 | ||
| decreased total retina thickness | 2 supporting datasets | Epc2tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 2.28x10-5 | ||
| abnormal behavior | 1 supporting dataset | Epc2tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 5.82x10-5 | ||
| thrombocytopenia | 1 supporting dataset | Epc2tm1a(EUCOMM)Wtsi | homozygote | Early adult | 2.38x10-6 | ||
| decreased locomotor activity | 1 supporting dataset | Epc2tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 6.74x10-5 | ||
| abnormal retina pigmentation | 1 supporting dataset | Epc2tm1a(EUCOMM)Wtsi | homozygote | Early adult | 4.95x10-5 |
| | | | | | | | | | |
Human diseases caused by Epc2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Epc2.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
| Epc2tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Epc2tm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Epc2tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell mouse |
| Epc2tm2a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Epc2tm34341(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |