Epc2 | enhancer of polycomb homolog 2

GeneMGI:1278321Synonyms: D2Ertd694e

Physiological systems

22 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Homeostasis/metabolism Pigmentation Vision/eye Respiratory system Hematopoietic system Behavior/neurological Cardiovascular system Mortality/aging

14 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:16Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Allele:

Phy. System:



abnormal retina morphology	1 supporting dataset	Epc2^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	2.77x10^-5
increased circulating alkaline phosphatase level	1 supporting dataset	Epc2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	8.85x10^-6
increased thigmotaxis	2 supporting datasets	Epc2^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	5.82x10^-5
decreased lactate dehydrogenase level	1 supporting dataset	Epc2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	3.01x10^-6
cataract	1 supporting dataset	Epc2^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	3.23x10^-8
decreased total retina thickness	2 supporting datasets	Epc2^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	2.28x10^-5
abnormal behavior	1 supporting dataset	Epc2^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	5.82x10^-5
thrombocytopenia	1 supporting dataset	Epc2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	2.38x10^-6
decreased locomotor activity	1 supporting dataset	Epc2^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	6.74x10^-5
abnormal retina pigmentation	1 supporting dataset	Epc2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	4.95x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Epc2.

Associated images

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Histopathology

There is no histopathology data found for Epc2.

IMPC related publications

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External links

No external links available for Epc2.

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*Epc2^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Epc2^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Epc2^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell mouse
*Epc2^{tm2a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Epc2^{tm34341(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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