Shmt2 | serine hydroxymethyltransferase 2 (mitochondrial)
Physiological systems
21 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Immune system Integument Embryo Growth/size/body region Hematopoietic system Mortality/aging Cardiovascular system
14 No significant impact
3 Not tested
Data collections
Gene metrics:7Significant phenotypes
1Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| increased spleen weight | 1 supporting dataset | Shmt2em1(IMPC)Bay | heterozygote | Early adult | 1.76x10-35 | ||
| preweaning lethality, complete penetrance | 3 supporting datasets | Shmt2em1(IMPC)Bay | homozygote | Early adult | N/A * | ||
| prenatal lethality | 1 supporting dataset | Shmt2em1(IMPC)Bay | homozygote | E18.5 | N/A * | ||
| abnormal placenta size | 1 supporting dataset | Shmt2em1(IMPC)Bay | homozygote | E12.5 | N/A * | ||
| pallor | 1 supporting dataset | Shmt2em1(IMPC)Bay | homozygote | E12.5 | N/A * | ||
| abnormal embryo size | 1 supporting dataset | Shmt2em1(IMPC)Bay | homozygote | E12.5 | N/A * | ||
| prolonged PR interval | 1 supporting dataset | Shmt2em1(IMPC)Bay | heterozygote | Early adult | 7.87x10-28 |
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External links
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| Shmt2em1(IMPC)Bay | Exon Deletion | | mouse |
| Shmt2tm1(KOMP)Mbp | Reporter-tagged deletion allele (with selection cassette) | | targeting vector ES Cell |
| Shmt2tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |