Dlg4 | discs large MAGUK scaffold protein 4

GeneMGI:1277959Synonyms: PSD95, SAP90, +3 more

Physiological systems

20 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Adipose tissue Growth/size/body region Behavior/neurological Skeleton

15 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Allele:

Phy. System:



abnormal behavior	3 supporting datasets	Dlg4^tm1Grnt	homozygote	Early adult	6.65x10^-7
decreased total body fat amount	1 supporting dataset	Dlg4^{tm1e(EUCOMM)Wtsi}	homozygote	Early adult	5.3x10^-5
increased lean body mass	1 supporting dataset	Dlg4^{tm1e(EUCOMM)Wtsi}	homozygote	Early adult	4.46x10^-6
decreased exploration in new environment	1 supporting dataset	Dlg4^tm1Grnt	homozygote	Early adult	6.95x10^-14
decreased body weight	5 supporting datasets	Dlg4^tm1Grnt	homozygote	Early adult	1.55x10^-8
tremors	1 supporting dataset	Dlg4^{tm1e(EUCOMM)Wtsi}	homozygote	Early adult	7.27x10^-9
decreased locomotor activity	1 supporting dataset	Dlg4^tm1Grnt	homozygote	Early adult	6.3x10^-5
decreased grip strength	2 supporting datasets	Dlg4^{tm1e(EUCOMM)Wtsi}	homozygote	Early adult	3.58x10^-8
increased bone mineral content	1 supporting dataset	Dlg4^{tm1e(EUCOMM)Wtsi}	homozygote	Early adult	5.89x10^-5
increased circulating sodium level	1 supporting dataset	Dlg4^{tm1e(EUCOMM)Wtsi}	homozygote	Early adult	4.56x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Dlg4.

Associated images

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Histopathology

There is no histopathology data found for Dlg4.

IMPC related publications

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External links

No external links available for Dlg4.

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*Dlg4^tm1Grnt*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Dlg4^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Dlg4^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	mouse

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