Vax1 | ventral anterior homeobox 1
GeneMGI:1277163
Physiological systems
18 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Homeostasis/metabolism Mortality/aging Cardiovascular system
15 No significant impact
6 Not tested
Data collections
Gene metrics:4Significant phenotypes
1Associated diseases
Expression examined in:50Adult tissues
50Embryo tissues
| preweaning lethality, incomplete penetrance | 1 supporting dataset | Vax1tm1b(KOMP)Mbp | homozygote | Early adult | N/A * | ||
| abnormal sinus arrhythmia | 1 supporting dataset | Vax1tm1b(KOMP)Mbp | heterozygote | Early adult | 6.49x10-5 | ||
| increased circulating alkaline phosphatase level | 1 supporting dataset | Vax1tm1b(KOMP)Mbp | heterozygote | Early adult | 2.23x10-5 | ||
| decreased circulating glucose level | 1 supporting dataset | Vax1tm1b(KOMP)Mbp | heterozygote | Early adult | 7.39x10-9 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| bone marrow | heterozygote | n/a | 0% (0/2) | 0% (0/22) |
| brain | heterozygote | Section images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | Section images | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | n/a | 0.22% (1/454) |
| cerebellum | heterozygote | Section images | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | Section images | 100% (2/2) | 0.41% (2/491) |
Human diseases caused by Vax1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Vax1.
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| Vax1tm1a(KOMP)Mbp | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Vax1tm1b(KOMP)Mbp | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Vax1tm1e(KOMP)Mbp | Targeted, non-conditional allele | | ES Cell |