Cdk6 | cyclin dependent kinase 6
Physiological systems
17 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Nervous system Vision/eye Hematopoietic system
14 No significant impact
7 Not tested
Data collections
Gene metrics:4Significant phenotypes
2Associated diseases
Expression examined in:73Adult tissues
0Embryo tissues
| abnormal eye morphology | 1 supporting dataset | Cdk6tm1b(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| small superior vagus ganglion | 1 supporting dataset | Cdk6tm1b(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| increased mean corpuscular hemoglobin | 1 supporting dataset | Cdk6tm1b(EUCOMM)Wtsi | homozygote | Early adult | 1.91x10-5 | ||
| increased mean corpuscular volume | 1 supporting dataset | Cdk6tm1b(EUCOMM)Wtsi | homozygote | Early adult | 2.55x10-6 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | Section images | 50% (1/2) | 0.19% (1/533) |
| blood | heterozygote | n/a | 0% (0/2) | 0% (0/17) |
| bone marrow | heterozygote | Section images | 50% (1/2) | 0% (0/22) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | Section images | 50% (1/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | n/a | 0.22% (1/454) |
| cecum | heterozygote | n/a | 0% (0/1) | 7.75% (22/284) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
Human diseases caused by Cdk6 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Cdk6.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
| Cdk6tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Cdk6tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Cdk6tm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Cdk6tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |
| Cdk6tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |