Cdk6 | cyclin dependent kinase 6

GeneMGI:1277162Synonyms: Crk2

Physiological systems

17 / 24 physiological systems tested

3 Significantly impacted by the knock-out

Nervous system Vision/eye Hematopoietic system

14 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:4Significant phenotypes

2Associated diseases

Expression examined in:73Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal eye morphology	1 supporting dataset	Cdk6^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
small superior vagus ganglion	1 supporting dataset	Cdk6^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
increased mean corpuscular hemoglobin	1 supporting dataset	Cdk6^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.91x10^-5
increased mean corpuscular volume	1 supporting dataset	Cdk6^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	2.55x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Cdk6.

Associated images

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Histopathology

There is no histopathology data found for Cdk6.

IMPC related publications

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External links

No external links available for Cdk6.

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*Cdk6^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Cdk6^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Cdk6^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Cdk6^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell
*Cdk6^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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