Ptp4a1 | protein tyrosine phosphatase 4a1

GeneMGI:1277096Synonyms: Prl-1

Physiological systems

18 / 24 physiological systems tested

11 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Immune system Integument Growth/size/body region Limbs/digits/tail Vision/eye Hematopoietic system Skeleton Cardiovascular system Renal/urinary system

7 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:16Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:

Life Stage:



decreased bone mineral content	1 supporting dataset	Ptp4a1^em2(IMPC)Tcp	homozygote	Early adult	6.31x10^-5
abnormal retina vasculature morphology	1 supporting dataset	Ptp4a1^em2(IMPC)Tcp	homozygote	Early adult	4.75x10^-5
microphthalmia	1 supporting dataset	Ptp4a1^em2(IMPC)Tcp	homozygote	Early adult	N/A ^*
small spleen	1 supporting dataset	Ptp4a1^em2(IMPC)Tcp	homozygote	Late adult	N/A ^*
abnormal skin morphology	1 supporting dataset	Ptp4a1^em2(IMPC)Tcp	homozygote	Late adult	N/A ^*
increased circulating alkaline phosphatase level	1 supporting dataset	Ptp4a1^em2(IMPC)Tcp	homozygote	Early adult	1.97x10^-6
abnormal heart morphology	1 supporting dataset	Ptp4a1^em2(IMPC)Tcp	homozygote	Late adult	N/A ^*
abnormal sternum morphology	1 supporting dataset	Ptp4a1^em2(IMPC)Tcp	homozygote	Late adult	N/A ^*
enlarged urinary bladder	1 supporting dataset	Ptp4a1^em2(IMPC)Tcp	homozygote	Late adult	N/A ^*
abnormal uterus morphology	1 supporting dataset	Ptp4a1^em2(IMPC)Tcp	homozygote	Late adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ptp4a1.

Associated images

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Histopathology

There is no histopathology data found for Ptp4a1.

IMPC related publications

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External links

No external links available for Ptp4a1.

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*Ptp4a1^em2(IMPC)Tcp*	Exon Deletion	‌	mouse
*Ptp4a1^{tm1(NCOM)Mfgc}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell
*Ptp4a1^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Ptp4a1^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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