Ptp4a1 | protein tyrosine phosphatase 4a1
Physiological systems
18 / 24 physiological systems tested
11 Significantly impacted by the knock-out
Homeostasis/metabolism Reproductive system Immune system Integument Growth/size/body region Limbs/digits/tail Vision/eye Hematopoietic system Skeleton Cardiovascular system Renal/urinary system
7 No significant impact
6 Not tested
Data collections
Gene metrics:16Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| decreased bone mineral content | 1 supporting dataset | Ptp4a1em2(IMPC)Tcp | homozygote | Early adult | 6.31x10-5 | ||
| abnormal retina vasculature morphology | 1 supporting dataset | Ptp4a1em2(IMPC)Tcp | homozygote | Early adult | 4.75x10-5 | ||
| microphthalmia | 1 supporting dataset | Ptp4a1em2(IMPC)Tcp | homozygote | Early adult | N/A * | ||
| small spleen | 1 supporting dataset | Ptp4a1em2(IMPC)Tcp | homozygote | Late adult | N/A * | ||
| abnormal skin morphology | 1 supporting dataset | Ptp4a1em2(IMPC)Tcp | homozygote | Late adult | N/A * | ||
| increased circulating alkaline phosphatase level | 1 supporting dataset | Ptp4a1em2(IMPC)Tcp | homozygote | Early adult | 1.97x10-6 | ||
| abnormal heart morphology | 1 supporting dataset | Ptp4a1em2(IMPC)Tcp | homozygote | Late adult | N/A * | ||
| abnormal sternum morphology | 1 supporting dataset | Ptp4a1em2(IMPC)Tcp | homozygote | Late adult | N/A * | ||
| enlarged urinary bladder | 1 supporting dataset | Ptp4a1em2(IMPC)Tcp | homozygote | Late adult | N/A * | ||
| abnormal uterus morphology | 1 supporting dataset | Ptp4a1em2(IMPC)Tcp | homozygote | Late adult | N/A * |
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Human diseases caused by Ptp4a1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Ptp4a1.
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| Ptp4a1em2(IMPC)Tcp | Exon Deletion | | mouse |
| Ptp4a1tm1(NCOM)Mfgc | Reporter-tagged deletion allele (with selection cassette) | | targeting vector ES Cell |
| Ptp4a1tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Ptp4a1tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |