Ncoa2 | nuclear receptor coactivator 2

GeneMGI:1276533Synonyms: glucocorticoid receptor-interacting protein 1, bHLHe75, +7 more

Physiological systems

21 / 24 physiological systems tested

12 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Integument Embryo Growth/size/body region Limbs/digits/tail Hearing/vestibular/ear Hematopoietic system Behavior/neurological Mortality/aging Cardiovascular system Renal/urinary system

9 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:20Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



decreased anxiety-related response	1 supporting dataset	Ncoa2^em1(IMPC)Mbp	heterozygote	Early adult	2.46x10^-9
increased circulating insulin level	1 supporting dataset	Ncoa2^em1(IMPC)Mbp	heterozygote	Early adult	2.73x10^-5
abnormal spleen morphology	1 supporting dataset	Ncoa2^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
abnormal placenta morphology	1 supporting dataset	Ncoa2^em1(IMPC)Mbp	heterozygote	E18.5	N/A ^*
increased neutrophil cell number	2 supporting datasets	Ncoa2^em1(IMPC)Mbp	heterozygote	Early adult	1.92x10^-5
abnormal placenta vasculature	1 supporting dataset	Ncoa2^em1(IMPC)Mbp	heterozygote	E18.5	N/A ^*
enlarged spleen	1 supporting dataset	Ncoa2^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
small kidney	1 supporting dataset	Ncoa2^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
no spontaneous movement	1 supporting dataset	Ncoa2^em1(IMPC)Mbp	heterozygote	E18.5	N/A ^*
abnormal placenta morphology	1 supporting dataset	Ncoa2^em1(IMPC)Mbp	homozygote	E18.5	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ncoa2.

Associated images

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Histopathology

There is no histopathology data found for Ncoa2.

IMPC related publications

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External links

No external links available for Ncoa2.

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*Ncoa2^em1(IMPC)Mbp*	Exon Deletion	‌	mouse
*Ncoa2^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell

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