Ncoa1 | nuclear receptor coactivator 1
Physiological systems
21 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Homeostasis/metabolism Adipose tissue Growth/size/body region Nervous system Respiratory system Behavior/neurological Skeleton
14 No significant impact
3 Not tested
Data collections
Gene metrics:10Significant phenotypes
0Associated diseases
Expression examined in:73Adult tissues
0Embryo tissues
| increased lean body mass | 1 supporting dataset | Ncoa1tm1.1(KOMP)Vlcg | homozygote | Early adult | 1.33x10-5 | ||
| hyperactivity | 4 supporting datasets | Ncoa1tm1.1(KOMP)Vlcg | homozygote | Early adult | 1.56x10-6 | ||
| increased circulating alkaline phosphatase level | 1 supporting dataset | Ncoa1tm1.1(KOMP)Vlcg | homozygote | Early adult | 8.75x10-8 | ||
| increased lung weight | 1 supporting dataset | Ncoa1tm1.1(KOMP)Vlcg | homozygote | Early adult | 2.78x10-6 | ||
| abnormal brain morphology | 1 supporting dataset | Ncoa1tm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| decreased total body fat amount | 1 supporting dataset | Ncoa1tm1.1(KOMP)Vlcg | homozygote | Early adult | 2.44x10-5 | ||
| increased grip strength | 2 supporting datasets | Ncoa1tm1.1(KOMP)Vlcg | homozygote | Early adult | 1.34x10-5 | ||
| increased bone mineral content | 1 supporting dataset | Ncoa1tm1.1(KOMP)Vlcg | homozygote | Early adult | 2.17x10-10 | ||
| hydrocephaly | 1 supporting dataset | Ncoa1tm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| decreased fasting circulating glucose level | 1 supporting dataset | Ncoa1tm1.1(KOMP)Vlcg | homozygote | Early adult | 7.9x10-5 |
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| adrenal gland | heterozygote | Section images | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | Section images | 100% (2/2) | 0.19% (1/533) |
| blood | heterozygote | n/a | 0% (0/2) | 0% (0/17) |
| bone marrow | heterozygote | n/a | 0% (0/2) | 0% (0/22) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | Section images | 50% (1/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | n/a | 0.22% (1/454) |
| cecum | heterozygote | n/a | 0% (0/1) | 7.75% (22/284) |
| cerebellum | heterozygote | Section images | 100% (2/2) | 0.56% (3/532) |
Human diseases caused by Ncoa1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Ncoa1.
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| Ncoa1tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| Ncoa1tm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |
| Ncoa1tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |