Ncoa1 | nuclear receptor coactivator 1

GeneMGI:1276523Synonyms: SRC-a/NCoA-1, SRC1, +4 more

Physiological systems

21 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Adipose tissue Growth/size/body region Nervous system Respiratory system Behavior/neurological Skeleton

14 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

0Associated diseases

Expression examined in:73Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased lean body mass	1 supporting dataset	Ncoa1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	1.33x10^-5
hyperactivity	4 supporting datasets	Ncoa1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	1.56x10^-6
increased circulating alkaline phosphatase level	1 supporting dataset	Ncoa1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	8.75x10^-8
increased lung weight	1 supporting dataset	Ncoa1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	2.78x10^-6
abnormal brain morphology	1 supporting dataset	Ncoa1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
decreased total body fat amount	1 supporting dataset	Ncoa1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	2.44x10^-5
increased grip strength	2 supporting datasets	Ncoa1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	1.34x10^-5
increased bone mineral content	1 supporting dataset	Ncoa1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	2.17x10^-10
hydrocephaly	1 supporting dataset	Ncoa1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
decreased fasting circulating glucose level	1 supporting dataset	Ncoa1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	7.9x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ncoa1.

Associated images

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Histopathology

There is no histopathology data found for Ncoa1.

IMPC related publications

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External links

No external links available for Ncoa1.

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*Ncoa1^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Ncoa1^{tm1.1(KOMP)Vlcg}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse
*Ncoa1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell

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