Trdmt1 | tRNA aspartic acid methyltransferase 1

GeneMGI:1274787Synonyms: Rnmt2, Dnmt2

Physiological systems

16 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Nervous system Vision/eye Hematopoietic system Behavior/neurological Cardiovascular system

11 No significant impact

8 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:6Significant phenotypes

0Associated diseases

Expression examined in:46Adult tissues

42Embryo tissues

Phenotypes

Zygosity:

Phy. System:



decreased prepulse inhibition	2 supporting datasets	Trdmt1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	2.55x10^-5
decreased grip strength	1 supporting dataset	Trdmt1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	8.62x10^-5
hyperactivity	2 supporting datasets	Trdmt1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	8.64x10^-5
abnormal retina morphology	1 supporting dataset	Trdmt1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.1x10^-6
decreased mean platelet volume	1 supporting dataset	Trdmt1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.36x10^-5
prolonged PR interval	1 supporting dataset	Trdmt1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	3.2x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Trdmt1.

Associated images

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Histopathology

There is no histopathology data found for Trdmt1.

IMPC related publications

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External links

No external links available for Trdmt1.

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*Trdmt1^{tm1(NCOM)Mfgc}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell
*Trdmt1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Trdmt1^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Trdmt1^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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