Dnaja1 | DnaJ heat shock protein family (Hsp40) member A1
Physiological systems
17 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Homeostasis/metabolism Behavior/neurological Mortality/aging
14 No significant impact
7 Not tested
Data collections
Gene metrics:5Significant phenotypes
0Associated diseases
Expression examined in:49Adult tissues
46Embryo tissues
| increased circulating sodium level | 1 supporting dataset | Dnaja1tm1.1(KOMP)Vlcg | heterozygote | Early adult | 1.18x10-11 | ||
| hyperactivity | 2 supporting datasets | Dnaja1tm1.1(KOMP)Vlcg | heterozygote | Early adult | 5.81x10-5 | ||
| increased grip strength | 2 supporting datasets | Dnaja1tm1.1(KOMP)Vlcg | heterozygote | Early adult | 2x10-5 | ||
| decreased grip strength | 1 supporting dataset | Dnaja1tm1.1(KOMP)Vlcg | heterozygote | Early adult | 1.13x10-5 | ||
| preweaning lethality, incomplete penetrance | 1 supporting dataset | Dnaja1tm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * |
| | | | | | | | | | |
| adrenal gland | heterozygote | Section images | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | Section images | 100% (2/2) | 0.19% (1/533) |
| bone marrow | heterozygote | Section images | 100% (2/2) | 0% (0/22) |
| brain | heterozygote | Section images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | Section images | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | Section images | 100% (2/2) | 0% (0/588) |
| cartilage tissue | heterozygote | Section images | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | Section images | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | Section images | 100% (2/2) | 0.41% (2/491) |
| epididymis | heterozygote | Section images | 100% (1/1) | 87.5% (21/24) |
Human diseases caused by Dnaja1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Dnaja1.
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| Dnaja1tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| Dnaja1tm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |
| Dnaja1tm358548(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |