Cand1 | cullin associated and neddylation disassociated 1
Physiological systems
22 / 24 physiological systems tested
14 Significantly impacted by the knock-out
Reproductive system Immune system Endocrine/exocrine gland Integument Growth/size/body region Hematopoietic system Cardiovascular system Craniofacial Renal/urinary system Homeostasis/metabolism Embryo Vision/eye Liver/biliary system Mortality/aging
8 No significant impact
2 Not tested
Data collections
Gene metrics:24Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal spleen morphology | 1 supporting dataset | Cand1em1(IMPC)Mbp | heterozygote | Late adult | N/A * | ||
| small testis | 1 supporting dataset | Cand1em1(IMPC)Mbp | heterozygote | Late adult | N/A * | ||
| enlarged gallbladder | 1 supporting dataset | Cand1em1(IMPC)Mbp | heterozygote | Late adult | N/A * | ||
| microphthalmia | 1 supporting dataset | Cand1em1(IMPC)Mbp | heterozygote | E15.5 | N/A * | ||
| enlarged spleen | 2 supporting datasets | Cand1em1(IMPC)Mbp | heterozygote | Late adult | N/A * | ||
| abnormal heart morphology | 1 supporting dataset | Cand1em1(IMPC)Mbp | heterozygote | Late adult | N/A * | ||
| edema | 1 supporting dataset | Cand1em1(IMPC)Mbp | homozygote | E15.5 | N/A * | ||
| abnormal lymph node morphology | 1 supporting dataset | Cand1em1(IMPC)Mbp | heterozygote | Late adult | N/A * | ||
| abnormal blood vessel morphology | 1 supporting dataset | Cand1em1(IMPC)Mbp | homozygote | E15.5 | N/A * | ||
| abnormal placenta morphology | 1 supporting dataset | Cand1em1(IMPC)Mbp | heterozygote | E15.5 | N/A * |
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Human diseases caused by Cand1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Cand1.
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| Cand1em1(IMPC)Mbp | Exon Deletion | | mouse |
| Cand1tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Cand1tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |