Dnmt3b | DNA methyltransferase 3B
GeneMGI:1261819
Physiological systems
22 / 24 physiological systems tested
8 Significantly impacted by the knock-out
Homeostasis/metabolism Embryo Growth/size/body region Digestive/alimentary Vision/eye Craniofacial Mortality/aging Cardiovascular system
14 No significant impact
2 Not tested
Data collections
Gene metrics:13Significant phenotypes
4Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| preweaning lethality, complete penetrance | 3 supporting datasets | Dnmt3bem1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| edema | 1 supporting dataset | Dnmt3bem1(IMPC)Mbp | homozygote | E15.5 | N/A * | ||
| cleft palate | 1 supporting dataset | Dnmt3bem1(IMPC)Mbp | homozygote | E15.5 | N/A * | ||
| abnormal blood vessel morphology | 1 supporting dataset | Dnmt3bem1(IMPC)Mbp | heterozygote | E15.5 | N/A * | ||
| abnormal head shape | 1 supporting dataset | Dnmt3bem1(IMPC)Mbp | homozygote | E15.5 | N/A * | ||
| hemorrhage | 1 supporting dataset | Dnmt3bem1(IMPC)Mbp | homozygote | E15.5 | N/A * | ||
| abnormal placenta vasculature | 1 supporting dataset | Dnmt3bem1(IMPC)Mbp | homozygote | E15.5 | N/A * | ||
| microcephaly | 1 supporting dataset | Dnmt3bem1(IMPC)Mbp | homozygote | E15.5 | N/A * | ||
| embryonic growth retardation | 1 supporting dataset | Dnmt3bem1(IMPC)Mbp | homozygote | E15.5 | N/A * | ||
| abnormal placenta morphology | 1 supporting dataset | Dnmt3bem1(IMPC)Mbp | homozygote | E15.5 | N/A * |
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Human diseases caused by Dnmt3b mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Dnmt3b.
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| Dnmt3bem1(IMPC)Mbp | Exon Deletion | | mouse |
| Dnmt3btm299884(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |