Dnmt3b | DNA methyltransferase 3B

Physiological systems

22 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Homeostasis/metabolism Embryo Growth/size/body region Digestive/alimentary Vision/eye Craniofacial Mortality/aging Cardiovascular system

14 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:13Significant phenotypes

4Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



preweaning lethality, complete penetrance	3 supporting datasets	Dnmt3b^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
edema	1 supporting dataset	Dnmt3b^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*
cleft palate	1 supporting dataset	Dnmt3b^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*
abnormal blood vessel morphology	1 supporting dataset	Dnmt3b^em1(IMPC)Mbp	heterozygote	E15.5	N/A ^*
abnormal head shape	1 supporting dataset	Dnmt3b^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*
hemorrhage	1 supporting dataset	Dnmt3b^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*
abnormal placenta vasculature	1 supporting dataset	Dnmt3b^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*
microcephaly	1 supporting dataset	Dnmt3b^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*
embryonic growth retardation	1 supporting dataset	Dnmt3b^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*
abnormal placenta morphology	1 supporting dataset	Dnmt3b^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Dnmt3b.

Associated images

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Histopathology

There is no histopathology data found for Dnmt3b.

IMPC related publications

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External links

No external links available for Dnmt3b.

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*Dnmt3b^em1(IMPC)Mbp*	Exon Deletion	‌	mouse
*Dnmt3b^{tm299884(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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