Casp8 | caspase 8

GeneMGI:1261423Synonyms: FLICE, MACH, +2 more

Physiological systems

23 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Immune system Growth/size/body region Liver/biliary system Hematopoietic system Cardiovascular system Mortality/aging Renal/urinary system

16 No significant impact

1 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

6Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



increased heart left ventricle size	1 supporting dataset	Casp8^{em1(IMPC)Ccpcz}	heterozygote	Early adult	2.65x10^-5
abnormal liver morphology	1 supporting dataset	Casp8^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*
thick ventricular wall	1 supporting dataset	Casp8^{em1(IMPC)Ccpcz}	heterozygote	Early adult	2.69x10^-5
abnormal heart morphology	1 supporting dataset	Casp8^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*
enlarged heart	1 supporting dataset	Casp8^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*
small kidney	1 supporting dataset	Casp8^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*
small liver	1 supporting dataset	Casp8^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*
preweaning lethality, incomplete penetrance	1 supporting dataset	Casp8^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
embryonic lethality prior to tooth bud stage	1 supporting dataset	Casp8^{em1(IMPC)Ccpcz}	homozygote	E12.5	N/A ^*
abnormal kidney morphology	1 supporting dataset	Casp8^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Casp8.

Associated images

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Histopathology

There is no histopathology data found for Casp8.

IMPC related publications

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External links

No external links available for Casp8.

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*Casp8^{em1(IMPC)Ccpcz}*	Exon Deletion	‌	mouse
*Casp8^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Casp8^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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