Cd46 | CD46 antigen, complement regulatory protein

GeneMGI:1203290Synonyms: Mcp, CD46

Physiological systems

15 / 24 physiological systems tested

1 Significantly impacted by the knock-out

 Cardiovascular system

14 No significant impact

9 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:1Significant phenotypes
3Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

prolonged RR interval1 supporting datasetCd46em1(IMPC)HhomozygoteEarly adult1.59x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

Human diseases caused by Cd46 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.






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Histopathology

IMPC related publications

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Cd46em1(IMPC)HExon Deletionmouse
Cd46tm94931(L1L2_Bact_P)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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