Itch | itchy, E3 ubiquitin protein ligase
Physiological systems
21 / 24 physiological systems tested
13 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Endocrine/exocrine gland Adipose tissue Growth/size/body region Digestive/alimentary Liver/biliary system Hematopoietic system Behavior/neurological Skeleton Cardiovascular system Craniofacial Renal/urinary system
8 No significant impact
3 Not tested
Data collections
Gene metrics:39Significant phenotypes
2Associated diseases
Expression examined in:46Adult tissues
42Embryo tissues
| increased basophil cell number | 1 supporting dataset | Itchtm1b(EUCOMM)Hmgu | homozygote | Early adult | 4.71x10-14 | ||
| decreased bone mineral density | 1 supporting dataset | Itchtm1b(EUCOMM)Hmgu | homozygote | Early adult | 1.46x10-17 | ||
| decreased circulating alkaline phosphatase level | 1 supporting dataset | Itchtm1b(EUCOMM)Hmgu | homozygote | Early adult | 1.12x10-28 | ||
| abnormal bone structure | 1 supporting dataset | Itchtm1b(EUCOMM)Hmgu | homozygote | Early adult | 1.1x10-21 | ||
| decreased mean corpuscular hemoglobin | 1 supporting dataset | Itchtm1b(EUCOMM)Hmgu | homozygote | Early adult | 2.67x10-17 | ||
| decreased hemoglobin content | 1 supporting dataset | Itchtm1b(EUCOMM)Hmgu | homozygote | Early adult | 5.68x10-36 | ||
| increased eosinophil cell number | 2 supporting datasets | Itchtm1b(EUCOMM)Hmgu | homozygote | Early adult | 6.26x10-62 | ||
| enlarged kidney | 1 supporting dataset | Itchtm1b(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
| decreased bone mineral content | 2 supporting datasets | Itchtm1b(EUCOMM)Hmgu | homozygote | Early adult | 3.11x10-34 | ||
| decreased hematocrit | 1 supporting dataset | Itchtm1b(EUCOMM)Hmgu | homozygote | Early adult | 1.53x10-7 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 100% (2/2) | 0.19% (1/533) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 100% (2/2) | 0.41% (2/491) |
| esophagus | heterozygote | n/a | 0% (0/2) | 1.67% (7/419) |
Human diseases caused by Itch mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Itch.
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| Itchtm1(NCOM)Cmhd | Reporter-tagged deletion allele (with selection cassette) | | targeting vector ES Cell |
| Itchtm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Itchtm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Itchtm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |