Ctbp2 | C-terminal binding protein 2
Physiological systems
18 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Homeostasis/metabolism Embryo Behavior/neurological Mortality/aging Cardiovascular system
13 No significant impact
6 Not tested
Data collections
Gene metrics:8Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| preweaning lethality, complete penetrance | 3 supporting datasets | Ctbp2em1(IMPC)Bay | homozygote | Early adult | N/A * | ||
| abnormal somite shape | 1 supporting dataset | Ctbp2em1(IMPC)Bay | homozygote | E9.5 | N/A * | ||
| abnormal pericardium morphology | 1 supporting dataset | Ctbp2em1(IMPC)Bay | homozygote | E9.5 | N/A * | ||
| abnormal heart morphology | 1 supporting dataset | Ctbp2em1(IMPC)Bay | homozygote | E9.5 | N/A * | ||
| edema | 1 supporting dataset | Ctbp2em1(IMPC)Bay | homozygote | E9.5 | N/A * | ||
| abnormal embryo turning | 1 supporting dataset | Ctbp2em1(IMPC)Bay | homozygote | E9.5 | N/A * | ||
| decreased exploration in new environment | 1 supporting dataset | Ctbp2em1(IMPC)Bay | heterozygote | Early adult | 5.54x10-5 | ||
| prenatal lethality prior to heart atrial septation | 1 supporting dataset | Ctbp2em1(IMPC)Bay | homozygote | E15.5 | N/A * |
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Human diseases caused by Ctbp2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Ctbp2.
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| Ctbp2em1(IMPC)Bay | Exon Deletion | | mouse |
| Ctbp2tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Ctbp2tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Ctbp2tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |
| Ctbp2tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |