Ctbp2 | C-terminal binding protein 2

GeneMGI:1201686Synonyms: Gtrgeo6, D7Ertd45e, +1 more

Physiological systems

18 / 24 physiological systems tested

5 Significantly impacted by the knock-out

 Homeostasis/metabolism Embryo Behavior/neurological Mortality/aging Cardiovascular system

13 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:8Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

preweaning lethality, complete penetrance3 supporting datasetsCtbp2em1(IMPC)BayhomozygoteEarly adultN/A * 
abnormal somite shape1 supporting datasetCtbp2em1(IMPC)BayhomozygoteE9.5N/A * 
abnormal pericardium morphology1 supporting datasetCtbp2em1(IMPC)BayhomozygoteE9.5N/A * 
abnormal heart morphology1 supporting datasetCtbp2em1(IMPC)BayhomozygoteE9.5N/A * 
edema1 supporting datasetCtbp2em1(IMPC)BayhomozygoteE9.5N/A * 
abnormal embryo turning1 supporting datasetCtbp2em1(IMPC)BayhomozygoteE9.5N/A * 
decreased exploration in new environment1 supporting datasetCtbp2em1(IMPC)BayheterozygoteEarly adult5.54x10-5 
prenatal lethality prior to heart atrial septation1 supporting datasetCtbp2em1(IMPC)BayhomozygoteE15.5N/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Human diseases caused by Ctbp2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.






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Histopathology

IMPC related publications

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Ctbp2em1(IMPC)BayExon Deletionmouse
Ctbp2tm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
Ctbp2tm1a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
Ctbp2tm1e(EUCOMM)HmguTargeted, non-conditional alleleES Cell
Ctbp2tm1e(EUCOMM)WtsiTargeted, non-conditional alleleES Cell

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