Smad3 | SMAD family member 3

GeneMGI:1201674Synonyms: Madh3, Smad 3

Physiological systems

16 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Hematopoietic system Mortality/aging

12 No significant impact

8 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:3Significant phenotypes

4Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



preweaning lethality, complete penetrance	1 supporting dataset	Smad3^em1(IMPC)H	homozygote	Early adult	N/A ^*
decreased circulating alkaline phosphatase level	1 supporting dataset	Smad3^em1(IMPC)H	heterozygote	Early adult	5.92x10^-6
decreased lymphocyte cell number	1 supporting dataset	Smad3^em1(IMPC)H	heterozygote	Early adult	1.04x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Smad3.

Associated images

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Histopathology

There is no histopathology data found for Smad3.

IMPC related publications

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External links

No external links available for Smad3.

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*Smad3^em1(IMPC)H*	Indel	‌	mouse
*Smad3^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Smad3^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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