Pitpnm1 | phosphatidylinositol transfer protein, membrane-associated 1

GeneMGI:1197524Synonyms: DRES9, RdgB

Physiological systems

20 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Adipose tissue Growth/size/body region Skeleton Cardiovascular system

15 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:9Significant phenotypes

0Associated diseases

Expression examined in:45Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased circulating glucose level	1 supporting dataset	Pitpnm1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	8.41x10^-5
decreased total body fat amount	1 supporting dataset	Pitpnm1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	2.46x10^-7
increased bone mineral density	1 supporting dataset	Pitpnm1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	2.3x10^-6
increased heart weight	1 supporting dataset	Pitpnm1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	3.05x10^-6
decreased body weight	1 supporting dataset	Pitpnm1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	4.73x10^-6
decreased circulating potassium level	1 supporting dataset	Pitpnm1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	2.56x10^-6
increased bone mineral content	1 supporting dataset	Pitpnm1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	8.8x10^-5
decreased circulating calcium level	1 supporting dataset	Pitpnm1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.62x10^-9
increased lean body mass	1 supporting dataset	Pitpnm1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.05x10^-8

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Pitpnm1.

Associated images

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Histopathology

There is no histopathology data found for Pitpnm1.

IMPC related publications

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External links

No external links available for Pitpnm1.

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*Pitpnm1^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Pitpnm1^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Pitpnm1^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Pitpnm1^{tm44617(L1L2_gt1)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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