Pole2 | polymerase (DNA directed), epsilon 2 (p59 subunit)
Physiological systems
22 / 24 physiological systems tested
13 Significantly impacted by the knock-out
Homeostasis/metabolism Reproductive system Immune system Integument Endocrine/exocrine gland Embryo Growth/size/body region Nervous system Vision/eye Liver/biliary system Hematopoietic system Cardiovascular system Mortality/aging
9 No significant impact
2 Not tested
Data collections
Gene metrics:19Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal heart morphology | 1 supporting dataset | Pole2em1(IMPC)Mbp | heterozygote | E9.5 | N/A * | ||
| abnormal skin morphology | 1 supporting dataset | Pole2em1(IMPC)Mbp | heterozygote | Late adult | N/A * | ||
| small heart | 2 supporting datasets | Pole2em1(IMPC)Mbp | heterozygote | Late adult | N/A * | ||
| impaired glucose tolerance | 1 supporting dataset | Pole2em1(IMPC)Mbp | heterozygote | Late adult | 6.35x10-6 | ||
| enlarged spleen | 1 supporting dataset | Pole2em1(IMPC)Mbp | heterozygote | Late adult | N/A * | ||
| abnormal uterus morphology | 1 supporting dataset | Pole2em1(IMPC)Mbp | heterozygote | Late adult | N/A * | ||
| abnormal liver morphology | 1 supporting dataset | Pole2em1(IMPC)Mbp | heterozygote | Late adult | N/A * | ||
| preweaning lethality, complete penetrance | 3 supporting datasets | Pole2em1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| abnormal embryo turning | 1 supporting dataset | Pole2em1(IMPC)Mbp | heterozygote | E9.5 | N/A * | ||
| abnormal spleen morphology | 2 supporting datasets | Pole2em1(IMPC)Mbp | heterozygote | Late adult | N/A * |
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Human diseases caused by Pole2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Pole2.
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| Pole2em1(IMPC)Mbp | Exon Deletion | | mouse |
| Pole2tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |