Rasa3 | RAS p21 protein activator 3
Physiological systems
20 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Homeostasis/metabolism Growth/size/body region Nervous system Behavior/neurological Cardiovascular system Mortality/aging
14 No significant impact
4 Not tested
Data collections
Gene metrics:9Significant phenotypes
0Associated diseases
Expression examined in:49Adult tissues
46Embryo tissues
| hemorrhage | 1 supporting dataset | Rasa3tm1b(KOMP)J | homozygote | E12.5 | N/A * | ||
| prenatal lethality prior to heart atrial septation | 1 supporting dataset | Rasa3tm1b(KOMP)J | homozygote | E15.5 | N/A * | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Rasa3tm1b(KOMP)J | homozygote | Early adult | N/A * | ||
| decreased circulating glucose level | 1 supporting dataset | Rasa3tm1b(KOMP)J | heterozygote | Early adult | 9.6x10-5 | ||
| abnormal forebrain morphology | 1 supporting dataset | Rasa3tm1b(KOMP)J | homozygote | E12.5 | N/A * | ||
| increased heart weight | 1 supporting dataset | Rasa3tm1b(KOMP)J | heterozygote | Early adult | 4.33x10-7 | ||
| abnormal sleep behavior | 1 supporting dataset | Rasa3tm1b(KOMP)J | heterozygote | Early adult | 6.19x10-5 | ||
| abnormal midbrain morphology | 1 supporting dataset | Rasa3tm1b(KOMP)J | homozygote | E12.5 | N/A * | ||
| decreased exploration in new environment | 1 supporting dataset | Rasa3tm1b(KOMP)J | heterozygote | Early adult | 5.53x10-5 |
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| adrenal gland | heterozygote | Section images | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | Section images | 100% (2/2) | 0.19% (1/533) |
| bone marrow | heterozygote | Section images | 100% (2/2) | 0% (0/22) |
| brain | heterozygote | Section images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | Section images | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | Section images | 100% (2/2) | 0% (0/588) |
| cartilage tissue | heterozygote | Section images | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | Section images | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | Section images | 100% (2/2) | 0.41% (2/491) |
| epididymis | heterozygote | Section images | 100% (1/1) | 87.5% (21/24) |
Human diseases caused by Rasa3 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Rasa3.
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| Rasa3tm1a(KOMP)J | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Rasa3tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Rasa3tm1b(KOMP)J | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Rasa3tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Rasa3tm47947(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |