Kdm1a | lysine (K)-specific demethylase 1A

GeneMGI:1196256Synonyms: Kdm1, Aof2, +2 more

Physiological systems

19 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Immune system Liver/biliary system Respiratory system Hematopoietic system Behavior/neurological Cardiovascular system Mortality/aging Renal/urinary system

11 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

3Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



decreased grip strength	1 supporting dataset	Kdm1a^{tm1(NCOM)Mfgc}	heterozygote	Early adult	9.25x10^-8
decreased locomotor activity	3 supporting datasets	Kdm1a^{tm1(NCOM)Mfgc}	heterozygote	Early adult	4.49x10^-6
increased eosinophil cell number	2 supporting datasets	Kdm1a^{tm1(NCOM)Mfgc}	heterozygote	Early adult	2.02x10^-15
small kidney	1 supporting dataset	Kdm1a^{tm1(NCOM)Mfgc}	heterozygote	Early adult	N/A ^*
small spleen	1 supporting dataset	Kdm1a^{tm1(NCOM)Mfgc}	heterozygote	Early adult	N/A ^*
small liver	1 supporting dataset	Kdm1a^{tm1(NCOM)Mfgc}	heterozygote	Early adult	N/A ^*
increased mean platelet volume	1 supporting dataset	Kdm1a^{tm1(NCOM)Mfgc}	heterozygote	Early adult	3.96x10^-6
increased basophil cell number	2 supporting datasets	Kdm1a^{tm1(NCOM)Mfgc}	heterozygote	Early adult	1.11x10^-26
preweaning lethality, complete penetrance	1 supporting dataset	Kdm1a^{tm1(NCOM)Mfgc}	homozygote	Early adult	N/A ^*
small lung	1 supporting dataset	Kdm1a^{tm1(NCOM)Mfgc}	heterozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Kdm1a.

Associated images

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Histopathology

There is no histopathology data found for Kdm1a.

IMPC related publications

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External links

No external links available for Kdm1a.

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*Kdm1a^{tm1(NCOM)Mfgc}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell mouse

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