Septin5 | septin 5

GeneMGI:1195461Synonyms: Pnutl1, Sept5, +1 more

Physiological systems

17 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Growth/size/body region Limbs/digits/tail Hematopoietic system Skeleton Mortality/aging

10 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:9Significant phenotypes

0Associated diseases

Expression examined in:76Adult tissues

50Embryo tissues

Phenotypes

Zygosity:

Phy. System:



decreased body length	1 supporting dataset	Septin5^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	7.7x10^-5
short tibia	1 supporting dataset	Septin5^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	6.68x10^-6
improved glucose tolerance	1 supporting dataset	Septin5^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.74x10^-5
thrombocytopenia	1 supporting dataset	Septin5^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	2.79x10^-10
small spleen	1 supporting dataset	Septin5^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	N/A ^*
abnormal bone structure	1 supporting dataset	Septin5^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	2.8x10^-5
decreased bone mineral density	1 supporting dataset	Septin5^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	4.75x10^-5
decreased bone mineral content	1 supporting dataset	Septin5^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.58x10^-6
preweaning lethality, incomplete penetrance	1 supporting dataset	Septin5^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Septin5.

Associated images

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Histopathology

There is no histopathology data found for Septin5.

IMPC related publications

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External links

No external links available for Septin5.

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*Septin5^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Septin5^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse

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