Abce1 | ATP-binding cassette, sub-family E member 1
Physiological systems
18 / 24 physiological systems tested
8 Significantly impacted by the knock-out
Homeostasis/metabolism Reproductive system Immune system Endocrine/exocrine gland Nervous system Vision/eye Hematopoietic system Mortality/aging
10 No significant impact
6 Not tested
Data collections
Gene metrics:13Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| decreased prepulse inhibition | 4 supporting datasets | Abce1tm1.1(KOMP)Vlcg | heterozygote | Early adult | 3.18x10-7 | ||
| preweaning lethality, complete penetrance | 3 supporting datasets | Abce1tm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| increased neutrophil cell number | 1 supporting dataset | Abce1tm1.1(KOMP)Vlcg | heterozygote | Early adult | 4.54x10-7 | ||
| increased large unstained cell number | 1 supporting dataset | Abce1tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 1.57x10-9 | ||
| anophthalmia | 1 supporting dataset | Abce1tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 4.38x10-5 | ||
| enlarged lymph nodes | 1 supporting dataset | Abce1tm1.1(KOMP)Vlcg | heterozygote | Early adult | N/A * | ||
| abnormal seminal vesicle morphology | 1 supporting dataset | Abce1tm1.1(KOMP)Vlcg | heterozygote | Early adult | N/A * | ||
| decreased circulating creatinine level | 1 supporting dataset | Abce1tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 2.36x10-5 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Abce1tm1b(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
| embryonic lethality prior to organogenesis | 1 supporting dataset | Abce1tm1b(EUCOMM)Hmgu | homozygote | E9.5 | N/A * |
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Human diseases caused by Abce1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Abce1.
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| Abce1tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| Abce1tm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |
| Abce1tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Abce1tm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Abce1tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |