Slc3a1 | solute carrier family 3, member 1

GeneMGI:1195264Synonyms: NTAA, D2H

Physiological systems

21 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Adipose tissue Growth/size/body region Hematopoietic system Skeleton Renal/urinary system

14 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:27Significant phenotypes

5Associated diseases

Expression examined in:73Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased blood urea nitrogen level	1 supporting dataset	Slc3a1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	2.25x10^-40
increased kidney weight	1 supporting dataset	Slc3a1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	3.16x10^-20
cystolithiasis	2 supporting datasets	Slc3a1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
small kidney	2 supporting datasets	Slc3a1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
enlarged kidney	1 supporting dataset	Slc3a1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
abnormal kidney morphology	2 supporting datasets	Slc3a1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
enlarged urinary bladder	1 supporting dataset	Slc3a1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
increased circulating cholesterol level	1 supporting dataset	Slc3a1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	2.85x10^-7
increased circulating alkaline phosphatase level	1 supporting dataset	Slc3a1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	2.74x10^-5
decreased mean corpuscular volume	1 supporting dataset	Slc3a1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	1.46x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Slc3a1.

Associated images

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Histopathology

There is no histopathology data found for Slc3a1.

IMPC related publications

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External links

No external links available for Slc3a1.

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*Slc3a1^{em1(IMPC)Cnrm}*		‌	mouse
*Slc3a1^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Slc3a1^{tm1.1(KOMP)Vlcg}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse
*Slc3a1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Slc3a1^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Slc3a1^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell
*Slc3a1^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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