Slc3a1 | solute carrier family 3, member 1
Physiological systems
21 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Adipose tissue Growth/size/body region Hematopoietic system Skeleton Renal/urinary system
14 No significant impact
3 Not tested
Data collections
Gene metrics:27Significant phenotypes
5Associated diseases
Expression examined in:73Adult tissues
0Embryo tissues
| increased blood urea nitrogen level | 1 supporting dataset | Slc3a1tm1.1(KOMP)Vlcg | homozygote | Early adult | 2.25x10-40 | ||
| increased kidney weight | 1 supporting dataset | Slc3a1tm1.1(KOMP)Vlcg | homozygote | Early adult | 3.16x10-20 | ||
| cystolithiasis | 2 supporting datasets | Slc3a1tm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| small kidney | 2 supporting datasets | Slc3a1tm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| enlarged kidney | 1 supporting dataset | Slc3a1tm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| abnormal kidney morphology | 2 supporting datasets | Slc3a1tm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| enlarged urinary bladder | 1 supporting dataset | Slc3a1tm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| increased circulating cholesterol level | 1 supporting dataset | Slc3a1tm1.1(KOMP)Vlcg | homozygote | Early adult | 2.85x10-7 | ||
| increased circulating alkaline phosphatase level | 1 supporting dataset | Slc3a1tm1.1(KOMP)Vlcg | homozygote | Early adult | 2.74x10-5 | ||
| decreased mean corpuscular volume | 1 supporting dataset | Slc3a1tm1.1(KOMP)Vlcg | homozygote | Early adult | 1.46x10-5 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| blood | heterozygote | n/a | 0% (0/2) | 0% (0/17) |
| bone marrow | heterozygote | n/a | 0% (0/1) | 0% (0/22) |
| brain | heterozygote | n/a | 0% (0/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | n/a | 0.22% (1/454) |
| cecum | heterozygote | n/a | n/a | 7.75% (22/284) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
Human diseases caused by Slc3a1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Slc3a1.
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| Slc3a1em1(IMPC)Cnrm | | mouse | |
| Slc3a1tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| Slc3a1tm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |
| Slc3a1tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Slc3a1tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Slc3a1tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |
| Slc3a1tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |