Man2b2 | mannosidase 2, alpha B2

GeneMGI:1195262Synonyms: 135 kDa alpha-D-mannosidase

Physiological systems

19 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Immune system Endocrine/exocrine gland Hematopoietic system Mortality/aging

13 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

0Associated diseases

Expression examined in:45Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased circulating fructosamine level	1 supporting dataset	Man2b2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	2.66x10^-6
small adrenal glands	1 supporting dataset	Man2b2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
increased neutrophil cell number	1 supporting dataset	Man2b2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	2.52x10^-9
decreased lymphocyte cell number	2 supporting datasets	Man2b2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	9.92x10^-9
enlarged lymph nodes	1 supporting dataset	Man2b2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
decreased circulating serum albumin level	1 supporting dataset	Man2b2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	5.64x10^-5
decreased circulating total protein level	1 supporting dataset	Man2b2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	3.55x10^-6
abnormal uterus morphology	1 supporting dataset	Man2b2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
increased eosinophil cell number	1 supporting dataset	Man2b2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	1.31x10^-5
preweaning lethality, incomplete penetrance	1 supporting dataset	Man2b2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Man2b2.

Associated images

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Histopathology

There is no histopathology data found for Man2b2.

IMPC related publications

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External links

No external links available for Man2b2.

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*Man2b2^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Man2b2^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Man2b2^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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