Man2b2 | mannosidase 2, alpha B2
Physiological systems
19 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Homeostasis/metabolism Reproductive system Immune system Endocrine/exocrine gland Hematopoietic system Mortality/aging
13 No significant impact
5 Not tested
Data collections
Gene metrics:10Significant phenotypes
0Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues
| decreased circulating fructosamine level | 1 supporting dataset | Man2b2tm1b(KOMP)Wtsi | homozygote | Early adult | 2.66x10-6 | ||
| small adrenal glands | 1 supporting dataset | Man2b2tm1b(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
| increased neutrophil cell number | 1 supporting dataset | Man2b2tm1b(KOMP)Wtsi | homozygote | Early adult | 2.52x10-9 | ||
| decreased lymphocyte cell number | 2 supporting datasets | Man2b2tm1b(KOMP)Wtsi | homozygote | Early adult | 9.92x10-9 | ||
| enlarged lymph nodes | 1 supporting dataset | Man2b2tm1b(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
| decreased circulating serum albumin level | 1 supporting dataset | Man2b2tm1b(KOMP)Wtsi | homozygote | Early adult | 5.64x10-5 | ||
| decreased circulating total protein level | 1 supporting dataset | Man2b2tm1b(KOMP)Wtsi | homozygote | Early adult | 3.55x10-6 | ||
| abnormal uterus morphology | 1 supporting dataset | Man2b2tm1b(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
| increased eosinophil cell number | 1 supporting dataset | Man2b2tm1b(KOMP)Wtsi | homozygote | Early adult | 1.31x10-5 | ||
| preweaning lethality, incomplete penetrance | 1 supporting dataset | Man2b2tm1b(KOMP)Wtsi | homozygote | Early adult | N/A * |
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| adrenal gland | heterozygote | n/a | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 100% (2/2) | 0.19% (1/533) |
| blood vessel | heterozygote | n/a | 0% (0/2) | 0% (0/173) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 0% (0/2) | 0.41% (2/491) |
Human diseases caused by Man2b2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Man2b2.
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| Man2b2tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Man2b2tm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Man2b2tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |