Gpc1 | glypican 1

GeneMGI:1194891

Physiological systems

20 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Immune system Nervous system Vision/eye Liver/biliary system Hematopoietic system Behavior/neurological

14 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal brain morphology	2 supporting datasets	Gpc1^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
small liver	1 supporting dataset	Gpc1^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
decreased brain size	2 supporting datasets	Gpc1^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
decreased brain weight	1 supporting dataset	Gpc1^em1(IMPC)Mbp	homozygote	Early adult	3.91x10^-7
enlarged lymph nodes	1 supporting dataset	Gpc1^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
abnormal lymph node morphology	1 supporting dataset	Gpc1^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
increased vertical activity	1 supporting dataset	Gpc1^em1(IMPC)Mbp	homozygote	Early adult	9.94x10^-7
abnormal liver morphology	1 supporting dataset	Gpc1^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
increased red blood cell distribution width	1 supporting dataset	Gpc1^em1(IMPC)Mbp	homozygote	Early adult	5.42x10^-7
abnormal eye morphology	1 supporting dataset	Gpc1^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Gpc1.

Associated images

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Histopathology

There is no histopathology data found for Gpc1.

IMPC related publications

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External links

No external links available for Gpc1.

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*Gpc1^em1(IMPC)Mbp*	Exon Deletion	‌	mouse
*Gpc1^{tm392263(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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