Npepps | aminopeptidase puromycin sensitive

GeneMGI:1101358Synonyms: Psa, MP100

Physiological systems

20 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Adipose tissue Growth/size/body region Vision/eye Hematopoietic system Behavior/neurological Skeleton Craniofacial

13 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:14Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased total retina thickness	2 supporting datasets	Npepps^{em1(IMPC)Hmgu}	homozygote	Early adult	8.31x10^-46
decreased bone mineral content	2 supporting datasets	Npepps^{em1(IMPC)Hmgu}	homozygote	Early adult	1.82x10^-11
absent teeth	1 supporting dataset	Npepps^{em1(IMPC)Hmgu}	homozygote	Early adult	3.02x10^-5
increased grip strength	2 supporting datasets	Npepps^{em1(IMPC)Hmgu}	homozygote	Early adult	8.7x10^-9
abnormal retina morphology	1 supporting dataset	Npepps^{em1(IMPC)Hmgu}	homozygote	Early adult	1.17x10^-19
decreased hemoglobin content	1 supporting dataset	Npepps^{em1(IMPC)Hmgu}	homozygote	Early adult	3.26x10^-5
abnormal tooth morphology	2 supporting datasets	Npepps^{em1(IMPC)Hmgu}	homozygote	Early adult	2.84x10^-20
decreased locomotor activity	5 supporting datasets	Npepps^{em1(IMPC)Hmgu}	homozygote	Early adult	2.44x10^-6
decreased vertical activity	1 supporting dataset	Npepps^{em1(IMPC)Hmgu}	homozygote	Early adult	6.16x10^-8
decreased erythrocyte cell number	1 supporting dataset	Npepps^{em1(IMPC)Hmgu}	homozygote	Early adult	4.68x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Npepps.

Associated images

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Histopathology

There is no histopathology data found for Npepps.

IMPC related publications

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External links

No external links available for Npepps.

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*Npepps^{em1(IMPC)Hmgu}*	Exon Deletion	‌	mouse
*Npepps^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Npepps^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	es cell
*Npepps^{tm2a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell

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