Ltbp3 | latent transforming growth factor beta binding protein 3

GeneMGI:1101355Synonyms: Ltbp2

Physiological systems

21 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Integument Growth/size/body region Hematopoietic system Behavior/neurological Skeleton Craniofacial Renal/urinary system

12 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

5Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



abnormal zygomatic bone morphology	1 supporting dataset	Ltbp3^{em1(IMPC)Ccpcz}	homozygote	Early adult	1.11x10^-12
abnormal spleen morphology	1 supporting dataset	Ltbp3^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*
abnormal maxilla morphology	1 supporting dataset	Ltbp3^{em1(IMPC)Ccpcz}	homozygote	Early adult	3.89x10^-12
decreased spleen weight	1 supporting dataset	Ltbp3^{em1(IMPC)Ccpcz}	heterozygote	Early adult	2.83x10^-8
abnormal cranium morphology	1 supporting dataset	Ltbp3^{em1(IMPC)Ccpcz}	homozygote	Early adult	9.1x10^-6
decreased respiratory quotient	1 supporting dataset	Ltbp3^{em1(IMPC)Ccpcz}	homozygote	Early adult	3.77x10^-5
increased grip strength	2 supporting datasets	Ltbp3^{em1(IMPC)Ccpcz}	homozygote	Early adult	3.23x10^-5
abnormal kidney morphology	1 supporting dataset	Ltbp3^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*
abnormal skin morphology	1 supporting dataset	Ltbp3^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal tooth morphology	1 supporting dataset	Ltbp3^{em1(IMPC)Ccpcz}	homozygote	Early adult	9.2x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ltbp3.

Associated images

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Histopathology

There is no histopathology data found for Ltbp3.

IMPC related publications

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External links

No external links available for Ltbp3.

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*Ltbp3^{em1(IMPC)Ccpcz}*	Intra-exon deletion	‌	mouse
*Ltbp3^tm1(KOMP)Mbp*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector es cell
*Ltbp3^{tm465303(Ifitm2_intron_L1L2_GT0_LF2A_LacZ_BetactP_neo)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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