Ltbp3 | latent transforming growth factor beta binding protein 3
Physiological systems
21 / 24 physiological systems tested
9 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Integument Growth/size/body region Hematopoietic system Behavior/neurological Skeleton Craniofacial Renal/urinary system
12 No significant impact
3 Not tested
Data collections
Gene metrics:11Significant phenotypes
5Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal zygomatic bone morphology | 1 supporting dataset | Ltbp3em1(IMPC)Ccpcz | homozygote | Early adult | 1.11x10-12 | ||
| abnormal spleen morphology | 1 supporting dataset | Ltbp3em1(IMPC)Ccpcz | heterozygote | Early adult | N/A * | ||
| abnormal maxilla morphology | 1 supporting dataset | Ltbp3em1(IMPC)Ccpcz | homozygote | Early adult | 3.89x10-12 | ||
| decreased spleen weight | 1 supporting dataset | Ltbp3em1(IMPC)Ccpcz | heterozygote | Early adult | 2.83x10-8 | ||
| abnormal cranium morphology | 1 supporting dataset | Ltbp3em1(IMPC)Ccpcz | homozygote | Early adult | 9.1x10-6 | ||
| decreased respiratory quotient | 1 supporting dataset | Ltbp3em1(IMPC)Ccpcz | homozygote | Early adult | 3.77x10-5 | ||
| increased grip strength | 2 supporting datasets | Ltbp3em1(IMPC)Ccpcz | homozygote | Early adult | 3.23x10-5 | ||
| abnormal kidney morphology | 1 supporting dataset | Ltbp3em1(IMPC)Ccpcz | heterozygote | Early adult | N/A * | ||
| abnormal skin morphology | 1 supporting dataset | Ltbp3em1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| abnormal tooth morphology | 1 supporting dataset | Ltbp3em1(IMPC)Ccpcz | homozygote | Early adult | 9.2x10-6 |
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Human diseases caused by Ltbp3 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Ltbp3.
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| Ltbp3em1(IMPC)Ccpcz | Intra-exon deletion | | mouse |
| Ltbp3tm1(KOMP)Mbp | Reporter-tagged deletion allele (with selection cassette) | | targeting vector ES Cell |
| Ltbp3tm465303(Ifitm2_intron_L1L2_GT0_LF2A_LacZ_BetactP_neo) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |