Celsr1 | cadherin, EGF LAG seven-pass G-type receptor 1

GeneMGI:1100883Synonyms: Crsh, Scy, +2 more

Physiological systems

22 / 24 physiological systems tested

12 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Endocrine/exocrine gland Integument Embryo Growth/size/body region Limbs/digits/tail Nervous system Vision/eye Behavior/neurological Mortality/aging Craniofacial

10 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:25Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Allele:

Phy. System:

Life Stage:



no spontaneous movement	1 supporting dataset	Celsr1^em1(IMPC)Mbp	heterozygote	E18.5	N/A ^*
abnormal retina morphology	1 supporting dataset	Celsr1^em1(IMPC)Mbp	heterozygote	Early adult	9.64x10^-5
male infertility	1 supporting dataset	Celsr1^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
preweaning lethality, incomplete penetrance	3 supporting datasets	Celsr1^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
preweaning lethality, complete penetrance	1 supporting dataset	Celsr1^Scy	homozygote	Early adult	N/A ^*
decreased circulating cholesterol level	1 supporting dataset	Celsr1^Scy	heterozygote	Early adult	5.62x10^-5
cataract	1 supporting dataset	Celsr1^em1(IMPC)Mbp	heterozygote	Early adult	6.35x10^-5
cornea opacity	1 supporting dataset	Celsr1^Crsh	heterozygote	Early adult	2.56x10^-5
abnormal placenta morphology	1 supporting dataset	Celsr1^em1(IMPC)Mbp	heterozygote	E18.5	N/A ^*
increased circulating cholesterol level	1 supporting dataset	Celsr1^Scy	heterozygote	Early adult	4.78x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Celsr1.

Associated images

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Histopathology

There is no histopathology data found for Celsr1.

IMPC related publications

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External links

No external links available for Celsr1.

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*Celsr1^em1(IMPC)Mbp*	Exon Deletion	‌	mouse
*Celsr1^{tm2a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Celsr1^{tm2e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell
*Celsr1^{tm3e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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