Prss12 | serine protease 12 neurotrypsin (motopsin)

GeneMGI:1100881Synonyms: motopsin, Bssp-3

Physiological systems

21 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Endocrine/exocrine gland Growth/size/body region Hearing/vestibular/ear Vision/eye Hematopoietic system

14 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:6Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



enlarged thymus	1 supporting dataset	Prss12^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal thymus morphology	1 supporting dataset	Prss12^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal eye morphology	1 supporting dataset	Prss12^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
decreased body weight	1 supporting dataset	Prss12^{em1(IMPC)Ccpcz}	homozygote	Early adult	7.62x10^-5
increased circulating lactate dehydrogenase level	1 supporting dataset	Prss12^{em1(IMPC)Ccpcz}	homozygote	Early adult	5.05x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Prss12.

Associated images

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Histopathology

There is no histopathology data found for Prss12.

IMPC related publications

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External links

No external links available for Prss12.

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*Prss12^{em1(IMPC)Ccpcz}*	Exon Deletion	‌	mouse
*Prss12^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Prss12^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell

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