Twf1 | twinfilin actin binding protein 1

GeneMGI:1100520Synonyms: A6, Twinfilin-1, +3 more

Physiological systems

20 / 24 physiological systems tested

5 Significantly impacted by the knock-out

 Homeostasis/metabolism Pigmentation Integument Adipose tissue Growth/size/body region

15 No significant impact

4 Not tested

Data collections

Viability data
Body weight measurements
Embryo imaging data
Gene metrics:5Significant phenotypes
0Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues

Phenotypes

abnormal coat/hair pigmentation1 supporting datasetTwf1tm1a(EUCOMM)WtsihomozygoteEarly adult6.43x10-6 
increased circulating amylase level1 supporting datasetTwf1tm1a(EUCOMM)WtsihomozygoteEarly adult8.32x10-16 
abnormal skin condition1 supporting datasetTwf1tm1a(EUCOMM)WtsihomozygoteEarly adult1.37x10-7 
increased lean body mass1 supporting datasetTwf1tm1a(EUCOMM)WtsihomozygoteEarly adult1.09x10-6 
decreased total body fat amount1 supporting datasetTwf1tm1a(EUCOMM)WtsihomozygoteEarly adult4.08x10-6 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Twf1tm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
es cell
Twf1tm1a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
es cell
mouse
Twf1tm1e(EUCOMM)WtsiTargeted, non-conditional allelees cell
Twf1tm46454(L1L2_gt1)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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