Cdk12 | cyclin dependent kinase 12
Physiological systems
21 / 24 physiological systems tested
9 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Growth/size/body region Liver/biliary system Hematopoietic system Behavior/neurological Mortality/aging Cardiovascular system Renal/urinary system
12 No significant impact
3 Not tested
Data collections
Gene metrics:16Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal urinary bladder morphology | 1 supporting dataset | Cdk12em1(IMPC)Tcp | heterozygote | Late adult | N/A * | ||
| abnormal spleen morphology | 1 supporting dataset | Cdk12em1(IMPC)Tcp | heterozygote | Early adult | N/A * | ||
| enlarged spleen | 1 supporting dataset | Cdk12em1(IMPC)Tcp | heterozygote | Late adult | N/A * | ||
| decreased erythrocyte cell number | 1 supporting dataset | Cdk12em1(IMPC)Tcp | heterozygote | Early adult | 1.03x10-9 | ||
| preweaning lethality, complete penetrance | 3 supporting datasets | Cdk12em1(IMPC)Tcp | homozygote | Early adult | N/A * | ||
| prenatal lethality prior to heart atrial septation | 1 supporting dataset | Cdk12em1(IMPC)Tcp | homozygote | E15.5 | N/A * | ||
| decreased exploration in new environment | 1 supporting dataset | Cdk12em1(IMPC)Tcp | heterozygote | Late adult | 9.81x10-5 | ||
| decreased hematocrit | 1 supporting dataset | Cdk12em1(IMPC)Tcp | heterozygote | Early adult | 4.72x10-12 | ||
| increased spleen weight | 1 supporting dataset | Cdk12em1(IMPC)Tcp | heterozygote | Early adult | 2.04x10-7 | ||
| increased red blood cell distribution width | 1 supporting dataset | Cdk12em1(IMPC)Tcp | heterozygote | Early adult | 6.5x10-6 |
| | | | | | | | | | |
Human diseases caused by Cdk12 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Cdk12.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
| Cdk12em1(IMPC)Tcp | Exon Deletion | | mouse |
| Cdk12tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Cdk12tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |