Lbp | lipopolysaccharide binding protein
Physiological systems
19 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Growth/size/body region Hematopoietic system
15 No significant impact
5 Not tested
Data collections
Gene metrics:4Significant phenotypes
0Associated diseases
Expression examined in:46Adult tissues
42Embryo tissues
| decreased eosinophil cell number | 1 supporting dataset | Lbptm1b(EUCOMM)Hmgu | homozygote | Early adult | 8.46x10-5 | ||
| increased fasting circulating glucose level | 1 supporting dataset | Lbptm1b(EUCOMM)Hmgu | homozygote | Early adult | 2.34x10-5 | ||
| increased circulating fructosamine level | 1 supporting dataset | Lbptm1b(EUCOMM)Hmgu | homozygote | Early adult | 1.28x10-5 | ||
| increased spleen weight | 1 supporting dataset | Lbptm1b(EUCOMM)Hmgu | homozygote | Early adult | 1.22x10-7 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 0% (0/2) | 0.41% (2/491) |
| esophagus | heterozygote | n/a | 0% (0/2) | 1.67% (7/419) |
Human diseases caused by Lbp mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Lbp.
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| Lbptm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Lbptm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Lbptm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Lbptm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |
| Lbptm29288(L1L2_gt1) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |