C9 | complement component 9
GeneMGI:1098282
Physiological systems
17 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Homeostasis/metabolism Growth/size/body region Cardiovascular system
14 No significant impact
7 Not tested
Data collections
Gene metrics:2Significant phenotypes
3Associated diseases
Expression examined in:48Adult tissues
46Embryo tissues
| increased circulating sodium level | 1 supporting dataset | C9tm1.1(KOMP)Vlcg | homozygote | Early adult | 5.36x10-8 | ||
| increased heart weight | 1 supporting dataset | C9tm1.1(KOMP)Vlcg | homozygote | Early adult | 6.01x10-5 |
| | | | | | | | | | |
| adrenal gland | heterozygote | Section images | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| brain | heterozygote | Section images | 50% (1/2) | 0.86% (5/579) |
| brainstem | heterozygote | Section images | 50% (1/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 0% (0/2) | 0.41% (2/491) |
| epididymis | heterozygote | n/a | 0% (0/1) | 87.5% (21/24) |
| esophagus | heterozygote | n/a | 0% (0/2) | 1.67% (7/419) |
Human diseases caused by C9 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for C9.
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| C9tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| C9tm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |
| C9tm44785(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |