Cyp27b1 | cytochrome P450, family 27, subfamily b, polypeptide 1

GeneMGI:1098274Synonyms: Vddr, 1alpha(OH)ase, +11 more

Physiological systems

16 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Adipose tissue Growth/size/body region Limbs/digits/tail Hematopoietic system Behavior/neurological Skeleton Craniofacial

7 No significant impact

8 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:32Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased locomotor activity	4 supporting datasets	Cyp27b1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	3.93x10^-8
decreased bone mineral density	1 supporting dataset	Cyp27b1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	7.78x10^-48
abnormal pelvic girdle bone morphology	1 supporting dataset	Cyp27b1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.83x10^-8
abnormal scapula morphology	1 supporting dataset	Cyp27b1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	9.26x10^-13
increased circulating aspartate transaminase level	1 supporting dataset	Cyp27b1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.01x10^-5
increased circulating alkaline phosphatase level	1 supporting dataset	Cyp27b1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	0
decreased circulating phosphate level	1 supporting dataset	Cyp27b1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	3.33x10^-5
abnormal radius morphology	1 supporting dataset	Cyp27b1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	9.26x10^-13
decreased exploration in new environment	2 supporting datasets	Cyp27b1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	4.78x10^-8
decreased total body fat amount	1 supporting dataset	Cyp27b1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	3.85x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Cyp27b1.

Associated images

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Histopathology

There is no histopathology data found for Cyp27b1.

IMPC related publications

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External links

No external links available for Cyp27b1.

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*Cyp27b1^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Cyp27b1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Cyp27b1^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Cyp27b1^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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