Rgs2 | regulator of G-protein signaling 2
Physiological systems
19 / 24 physiological systems tested
9 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Growth/size/body region Vision/eye Hematopoietic system Behavior/neurological Skeleton Craniofacial Cardiovascular system
10 No significant impact
5 Not tested
Data collections
Gene metrics:8Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| prolonged PR interval | 1 supporting dataset | Rgs2em1(IMPC)H | heterozygote | Early adult | 5.21x10-5 | ||
| abnormal tooth morphology | 2 supporting datasets | Rgs2em1(IMPC)H | homozygote | Early adult | 9.67x10-7 | ||
| cornea opacity | 1 supporting dataset | Rgs2em1(IMPC)H | homozygote | Late adult | 7.68x10-5 | ||
| decreased fasting circulating glucose level | 1 supporting dataset | Rgs2em1(IMPC)H | homozygote | Early adult | 8.51x10-6 | ||
| enlarged spleen | 1 supporting dataset | Rgs2em1(IMPC)H | homozygote | Late adult | N/A * | ||
| increased freezing behavior | 1 supporting dataset | Rgs2em1(IMPC)H | homozygote | Late adult | 2.15x10-8 | ||
| increased circulating creatinine level | 1 supporting dataset | Rgs2em1(IMPC)H | homozygote | Late adult | 8.89x10-9 | ||
| increased large unstained cell number | 1 supporting dataset | Rgs2em1(IMPC)H | heterozygote | Early adult | 6.95x10-5 |
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Human diseases caused by Rgs2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Rgs2.
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| Rgs2em1(IMPC)H | Exon Deletion | | mouse |
| Rgs2tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Rgs2tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Rgs2tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |