Ogdh | oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)

GeneMGI:1098267Synonyms: 2210412K19Rik, 2210403E04Rik, +2 more

Physiological systems

18 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Adipose tissue Growth/size/body region Hematopoietic system Behavior/neurological Mortality/aging

13 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:7Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



decreased hemoglobin content	1 supporting dataset	Ogdh^{tm1e(KOMP)Wtsi}	heterozygote	Early adult	2.09x10^-5
decreased total body fat amount	2 supporting datasets	Ogdh^{tm1e(KOMP)Wtsi}	heterozygote	Early adult	1.06x10^-7
increased grip strength	2 supporting datasets	Ogdh^{tm1e(KOMP)Wtsi}	heterozygote	Early adult	3.65x10^-5
decreased hematocrit	1 supporting dataset	Ogdh^{tm1e(KOMP)Wtsi}	heterozygote	Early adult	1.52x10^-7
increased lean body mass	1 supporting dataset	Ogdh^{tm1e(KOMP)Wtsi}	heterozygote	Early adult	7.65x10^-6
decreased erythrocyte cell number	1 supporting dataset	Ogdh^{tm1e(KOMP)Wtsi}	heterozygote	Early adult	2.12x10^-6
preweaning lethality, complete penetrance	1 supporting dataset	Ogdh^{tm1e(KOMP)Wtsi}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ogdh.

Associated images

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Histopathology

There is no histopathology data found for Ogdh.

IMPC related publications

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External links

No external links available for Ogdh.

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*Ogdh^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Ogdh^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell mouse

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