Ezh1 | enhancer of zeste 1 polycomb repressive complex 2 subunit

Physiological systems

18 / 24 physiological systems tested

4 Significantly impacted by the knock-out

 Homeostasis/metabolism Reproductive system Nervous system Hematopoietic system

14 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:6Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

decreased erythrocyte cell number1 supporting datasetEzh1tm1b(EUCOMM)WtsihomozygoteEarly adult1.14x10-5 
decreased hematocrit1 supporting datasetEzh1tm1b(EUCOMM)WtsihomozygoteEarly adult3.19x10-5 
increased circulating glucose level1 supporting datasetEzh1tm1b(EUCOMM)WtsihomozygoteEarly adult7.19x10-21 
decreased red blood cell distribution width1 supporting datasetEzh1tm1b(EUCOMM)WtsihomozygoteEarly adult8.4x10-5 
decreased prepulse inhibition3 supporting datasetsEzh1tm1b(EUCOMM)WtsihomozygoteEarly adult5.83x10-5 
male infertility1 supporting datasetEzh1tm1b(EUCOMM)WtsihomozygoteEarly adultN/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Ezh1tm1a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Ezh1tm1b(EUCOMM)WtsiReporter-tagged deletion allele (with selection cassette)mouse
Ezh1tm1e(EUCOMM)WtsiTargeted, non-conditional alleleES Cell

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