Ptgis | prostaglandin I2 (prostacyclin) synthase

GeneMGI:1097156Synonyms: Pgis, Pgi2, +1 more

Physiological systems

19 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Reproductive system Immune system Endocrine/exocrine gland Growth/size/body region Nervous system Hematopoietic system Cardiovascular system Renal/urinary system

11 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:19Significant phenotypes

1Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal kidney morphology	2 supporting datasets	Ptgis^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
abnormal lymph node morphology	2 supporting datasets	Ptgis^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
increased heart weight	2 supporting datasets	Ptgis^em1(IMPC)Mbp	homozygote	Early adult	5.34x10^-13
small kidney	2 supporting datasets	Ptgis^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
increased brain size	1 supporting dataset	Ptgis^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
enlarged lymph nodes	2 supporting datasets	Ptgis^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
polycystic kidney	1 supporting dataset	Ptgis^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
enlarged thymus	1 supporting dataset	Ptgis^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
abnormal testis morphology	1 supporting dataset	Ptgis^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
increased red blood cell distribution width	1 supporting dataset	Ptgis^em1(IMPC)Mbp	homozygote	Early adult	3.95x10^-9

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ptgis.

Associated images

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Histopathology

There is no histopathology data found for Ptgis.

IMPC related publications

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External links

No external links available for Ptgis.

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*Ptgis^em1(IMPC)Mbp*	Exon Deletion	‌	mouse
*Ptgis^{tm33670(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector
*Ptgis^{tm33670(L1L2_st2)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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