Pias2 | protein inhibitor of activated STAT 2

GeneMGI:1096566Synonyms: Miz1, PIASxb, +5 more

Physiological systems

20 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Adipose tissue Growth/size/body region Limbs/digits/tail Vision/eye Behavior/neurological Skeleton

13 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Allele:

Phy. System:



increased circulating insulin level	1 supporting dataset	Pias2^{tm1a(KOMP)Wtsi}	homozygote	Early adult	3.42x10^-5
abnormal digit morphology	1 supporting dataset	Pias2^{tm1a(KOMP)Wtsi}	homozygote	Early adult	5.35x10^-5
abnormal retina morphology	1 supporting dataset	Pias2^{tm1a(KOMP)Wtsi}	homozygote	Early adult	7.71x10^-6
decreased lean body mass	1 supporting dataset	Pias2^{tm1a(KOMP)Wtsi}	homozygote	Early adult	6.82x10^-5
decreased body length	1 supporting dataset	Pias2^{tm1a(KOMP)Wtsi}	homozygote	Early adult	1.46x10^-5
abnormal bone structure	1 supporting dataset	Pias2^{tm1a(KOMP)Wtsi}	homozygote	Early adult	1.38x10^-8
abnormal gait	1 supporting dataset	Pias2^{Gt(pT1Betageo)1Ruiz}	homozygote	Early adult	1.5x10^-6
abnormal social/conspecific interaction behavior	1 supporting dataset	Pias2^{Gt(pT1Betageo)1Ruiz}	homozygote	Early adult	7.06x10^-10
decreased bone mineral content	1 supporting dataset	Pias2^{tm1a(KOMP)Wtsi}	homozygote	Early adult	4.94x10^-7
increased total body fat amount	1 supporting dataset	Pias2^{tm1a(KOMP)Wtsi}	homozygote	Early adult	8.09x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Pias2.

Associated images

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Histopathology

There is no histopathology data found for Pias2.

IMPC related publications

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External links

No external links available for Pias2.

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*Pias2^{tm119215(L1L2_Pgk_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector
*Pias2^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse

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