Nrxn1 | neurexin I

GeneMGI:1096391Synonyms: alpha-latrotoxin receptor (calcium-dependent), neurexin I beta, +4 more

Physiological systems

19 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Adipose tissue Growth/size/body region Respiratory system Hematopoietic system Behavior/neurological Skeleton

11 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:19Significant phenotypes

3Associated diseases

Expression examined in:46Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



increased neutrophil cell number	2 supporting datasets	Nrxn1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	2.39x10^-15
increased circulating amylase level	1 supporting dataset	Nrxn1^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	2.35x10^-6
decreased grip strength	2 supporting datasets	Nrxn1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	2.09x10^-6
decreased pulmonary respiratory rate	1 supporting dataset	Nrxn1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	2.22x10^-5
increased lean body mass	1 supporting dataset	Nrxn1^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	4.36x10^-5
decreased total body fat amount	2 supporting datasets	Nrxn1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	1.56x10^-5
tremors	1 supporting dataset	Nrxn1^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	2.97x10^-5
increased circulating aspartate transaminase level	1 supporting dataset	Nrxn1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	7.87x10^-5
decreased circulating alkaline phosphatase level	1 supporting dataset	Nrxn1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	1.07x10^-7
increased neutrophil cell number	1 supporting dataset	Nrxn1^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	7.75x10^-8

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Nrxn1.

Associated images

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Histopathology

There is no histopathology data found for Nrxn1.

IMPC related publications

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External links

No external links available for Nrxn1.

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*Nrxn1^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Nrxn1^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse

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