Fgf15 | fibroblast growth factor 15
Physiological systems
22 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Homeostasis/metabolism Embryo Growth/size/body region Nervous system Mortality/aging Cardiovascular system
16 No significant impact
2 Not tested
Gene metrics:7Significant phenotypes
0Associated diseases
Expression examined in:41Adult tissues
29Embryo tissues
| abnormal brain morphology | 1 supporting dataset | Fgf15tm1.1(KOMP)Vlcg | heterozygote | Early adult | N/A * | ||
| preweaning lethality, complete penetrance | 3 supporting datasets | Fgf15tm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| edema | 1 supporting dataset | Fgf15tm1.1(KOMP)Vlcg | homozygote | E15.5 | N/A * | ||
| hydrocephaly | 1 supporting dataset | Fgf15tm1.1(KOMP)Vlcg | heterozygote | Early adult | N/A * | ||
| abnormal heart morphology | 1 supporting dataset | Fgf15tm1.1(KOMP)Vlcg | homozygote | E15.5 | N/A * | ||
| abnormal embryo size | 1 supporting dataset | Fgf15tm1.1(KOMP)Vlcg | homozygote | E12.5 | N/A * | ||
| abnormal placenta size | 1 supporting dataset | Fgf15tm1.1(KOMP)Vlcg | homozygote | E12.5 | N/A * | ||
| abnormal embryo size | 1 supporting dataset | Fgf15tm1.1(KOMP)Vlcg | homozygote | E15.5 | N/A * |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| brain | heterozygote | Section images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/2) | 0.41% (2/490) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 0% (0/2) | 0.41% (2/491) |
| esophagus | heterozygote | n/a | 0% (0/2) | 1.67% (7/419) |
| eye | heterozygote | n/a | 0% (0/2) | 0% (0/335) |
| heart | heterozygote | n/a | 0% (0/2) | 0.36% (2/550) |
External links
No external links available for Fgf15.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
| Fgf15tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| Fgf15tm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |
| Fgf15tm213553(L1L2_Bact_P) | Reporter-tagged deletion allele (with selection cassette) | | targeting vector |