Nrxn2 | neurexin II

GeneMGI:1096362Synonyms: neurexin II beta, 6430591O13Rik, +1 more

Physiological systems

19 / 24 physiological systems tested

4 Significantly impacted by the knock-out

 Homeostasis/metabolism Growth/size/body region Behavior/neurological Cardiovascular system

15 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:11Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

abnormal gait1 supporting datasetNrxn2em1(IMPC)HhomozygoteEarly adult4.31x10-5 
hyperactivity1 supporting datasetNrxn2em1(IMPC)HhomozygoteLate adult6.83x10-6 
trunk curl1 supporting datasetNrxn2em1(IMPC)HhomozygoteEarly adult6.64x10-6 
enlarged heart1 supporting datasetNrxn2em1(IMPC)HhomozygoteLate adultN/A * 
increased blood urea nitrogen level1 supporting datasetNrxn2em1(IMPC)HhomozygoteEarly adult2.34x10-12 
increased lean body mass1 supporting datasetNrxn2em1(IMPC)HhomozygoteLate adult6.91x10-5 
decreased locomotor activity4 supporting datasetsNrxn2em1(IMPC)HhomozygoteEarly adult2.6x10-5 
tremors1 supporting datasetNrxn2em1(IMPC)HhomozygoteLate adult4.76x10-5 
increased circulating cholesterol level1 supporting datasetNrxn2em1(IMPC)HhomozygoteEarly adult1.29x10-8 
increased circulating total protein level1 supporting datasetNrxn2em1(IMPC)HhomozygoteEarly adult3.74x10-7 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Nrxn2em1(IMPC)HExon Deletionmouse

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