Wrn | Werner syndrome RecQ like helicase

Physiological systems

21 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Reproductive system Immune system Integument Endocrine/exocrine gland Growth/size/body region Hematopoietic system Behavior/neurological

14 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:5Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal spleen morphology	2 supporting datasets	Wrn^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
increased freezing behavior	1 supporting dataset	Wrn^{em1(IMPC)Ccpcz}	homozygote	Early adult	5.82x10^-7
abnormal ovary morphology	1 supporting dataset	Wrn^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal skin morphology	2 supporting datasets	Wrn^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
enlarged ovary	1 supporting dataset	Wrn^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Wrn.

Associated images

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Histopathology

There is no histopathology data found for Wrn.

IMPC related publications

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External links

No external links available for Wrn.

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*Wrn^{em1(IMPC)Ccpcz}*	Exon Deletion	‌	mouse

My Genes