Nck1 | non-catalytic region of tyrosine kinase adaptor protein 1

GeneMGI:109601Synonyms: Nck, D230010O13Rik, +1 more

Physiological systems

17 / 24 physiological systems tested

3 Significantly impacted by the knock-out

Homeostasis/metabolism Integument Vision/eye

14 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:5Significant phenotypes

0Associated diseases

Expression examined in:73Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal eye morphology	1 supporting dataset	Nck1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
increased circulating aspartate transaminase level	1 supporting dataset	Nck1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1x10^-5
abnormal skin morphology	1 supporting dataset	Nck1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
increased circulating alanine transaminase level	1 supporting dataset	Nck1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	4.11x10^-32
increased circulating alkaline phosphatase level	1 supporting dataset	Nck1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	2.35x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Nck1.

Associated images

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Histopathology

There is no histopathology data found for Nck1.

IMPC related publications

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External links

No external links available for Nck1.

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*Nck1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Nck1^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Nck1^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Nck1^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell
*Nck1^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

My Genes