Tnfrsf11b | tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)

GeneMGI:109587Synonyms: TR1, osteoclastogenesis inhibitory factor, +3 more

Physiological systems

20 / 24 physiological systems tested

14 Significantly impacted by the knock-out

Reproductive system Immune system Endocrine/exocrine gland Integument Growth/size/body region Hearing/vestibular/ear Hematopoietic system Renal/urinary system Homeostasis/metabolism Nervous system Vision/eye Behavior/neurological Skeleton Mortality/aging

6 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:27Significant phenotypes

3Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased bone mineral content	2 supporting datasets	Tnfrsf11b^em1(IMPC)Mbp	homozygote	Early adult	3.77x10^-17
decreased locomotor activity	2 supporting datasets	Tnfrsf11b^em1(IMPC)Mbp	homozygote	Early adult	4.16x10^-7
decreased brain size	1 supporting dataset	Tnfrsf11b^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
abnormal gait	1 supporting dataset	Tnfrsf11b^em1(IMPC)Mbp	homozygote	Early adult	8.13x10^-5
abnormal vitreous body morphology	1 supporting dataset	Tnfrsf11b^em1(IMPC)Mbp	homozygote	Early adult	5.26x10^-5
abnormal eye morphology	1 supporting dataset	Tnfrsf11b^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
abnormal auditory brainstem response	4 supporting datasets	Tnfrsf11b^em1(IMPC)Mbp	homozygote	Early adult	1.38x10^-5
abnormal seminal vesicle morphology	1 supporting dataset	Tnfrsf11b^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
abnormal skin morphology	2 supporting datasets	Tnfrsf11b^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
decreased grip strength	1 supporting dataset	Tnfrsf11b^em1(IMPC)Mbp	homozygote	Early adult	7.14x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Tnfrsf11b.

Associated images

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Histopathology

There is no histopathology data found for Tnfrsf11b.

IMPC related publications

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External links

No external links available for Tnfrsf11b.

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*Tnfrsf11b^em1(IMPC)Mbp*	Exon Deletion	‌	mouse
*Tnfrsf11b^{tm1(NCOM)Mfgc}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell
*Tnfrsf11b^tm1aNarl*	KO first allele (reporter-tagged insertion with conditional potential)	‌	ES Cell

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