Psmc2 | proteasome (prosome, macropain) 26S subunit, ATPase 2

GeneMGI:109555

Physiological systems

20 / 24 physiological systems tested

3 Significantly impacted by the knock-out

Homeostasis/metabolism Behavior/neurological Mortality/aging

17 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:5Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



increased circulating bilirubin level	1 supporting dataset	Psmc2^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	9.14x10^-5
decreased circulating alkaline phosphatase level	1 supporting dataset	Psmc2^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	9.86x10^-5
decreased circulating total protein level	1 supporting dataset	Psmc2^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	4.74x10^-6
abnormal gait	1 supporting dataset	Psmc2^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	5.58x10^-6
preweaning lethality, complete penetrance	1 supporting dataset	Psmc2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Psmc2.

Associated images

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Histopathology

There is no histopathology data found for Psmc2.

IMPC related publications

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External links

No external links available for Psmc2.

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*Psmc2^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Psmc2^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Psmc2^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell

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