Slc2a2 | solute carrier family 2 (facilitated glucose transporter), member 2
Physiological systems
17 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Homeostasis/metabolism Hematopoietic system Mortality/aging
14 No significant impact
7 Not tested
Data collections
Gene metrics:3Significant phenotypes
3Associated diseases
Expression examined in:76Adult tissues
25Embryo tissues
| increased glycosylated hemoglobin level | 1 supporting dataset | Slc2a2tm1b(KOMP)Wtsi | heterozygote | Early adult | 1.12x10-5 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Slc2a2tm1b(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
| increased fasting circulating glucose level | 1 supporting dataset | Slc2a2tm1b(KOMP)Wtsi | heterozygote | Early adult | 9.09x10-5 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/4) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/4) | 0.19% (1/533) |
| bone | heterozygote | Wholemount images | n/a | 0% (0/394) |
| brain | heterozygote | n/a | 0% (0/4) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/4) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/4) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | n/a | 0.22% (1/454) |
| cecum | heterozygote | Wholemount images | n/a | 7.75% (22/284) |
| cerebellum | heterozygote | n/a | 0% (0/4) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 0% (0/4) | 0.41% (2/491) |
Human diseases caused by Slc2a2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Slc2a2.
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| Slc2a2tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Slc2a2tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Slc2a2tm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Slc2a2tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |