Trpc3 | transient receptor potential cation channel, subfamily C, member 3

GeneMGI:109526Synonyms: Trrp3, Trcp3, +1 more

Physiological systems

21 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Homeostasis/metabolism Growth/size/body region Limbs/digits/tail Vision/eye Hematopoietic system Behavior/neurological Skeleton Cardiovascular system Mortality/aging

12 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:13Significant phenotypes

2Associated diseases

Expression examined in:76Adult tissues

25Embryo tissues

Phenotypes

Zygosity:

Allele:

Phy. System:



increased lean body mass	1 supporting dataset	Trpc3^Mwk	heterozygote	Early adult	8.51x10^-8
abnormal forelimb morphology	1 supporting dataset	Trpc3^Mwk	heterozygote	Early adult	3.2x10^-13
decreased circulating amylase level	1 supporting dataset	Trpc3^Mwk	heterozygote	Early adult	7.11x10^-5
increased circulating iron level	1 supporting dataset	Trpc3^Mwk	heterozygote	Early adult	1.47x10^-5
abnormal locomotor activation	1 supporting dataset	Trpc3^Mwk	heterozygote	Early adult	5.49x10^-8
abnormal response to new environment	1 supporting dataset	Trpc3^Mwk	heterozygote	Early adult	5.87x10^-5
abnormal gait	1 supporting dataset	Trpc3^Mwk	heterozygote	Early adult	2.71x10^-7
preweaning lethality, complete penetrance	1 supporting dataset	Trpc3^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
increased mean corpuscular volume	1 supporting dataset	Trpc3^Mwk	heterozygote	Early adult	3.9x10^-6
limb grasping	1 supporting dataset	Trpc3^Mwk	heterozygote	Early adult	1.28x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Trpc3.

Associated images

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Histopathology

There is no histopathology data found for Trpc3.

IMPC related publications

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External links

No external links available for Trpc3.

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*Trpc3^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Trpc3^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Trpc3^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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